Description
A NSAID and COX-2 inhibitor; binds to COX-2 (Kd = 4 nM) and inhibits COX-2-dependent oxygenation of arachidonic acid in vitro (Ki = 10 µM); reduces acetic acid-induced writhing in rats at 30 mg/kg; inhibits DNBC-induced increases in skin thickness in a mouse model of delayed-type hypersensitivity; reduces the antibody response to sheep red blood cells in mice